产品货号：
Z22302
中文名称：
NRF2/NFE2L2抗体
英文名称：
Anti-NRF2/NFE2L2 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-NRF2/NFE2L2 Antibody |
| 指标别名 | HEBP1;NF E2 related factor 2;NFE2 related factor 2;NFE2L2;NRF2;NRF2;NFE2L2 |
| 克隆性 | Polyclonal |
| 检验物种 | human |
| 应用范围 | WB,IHC,ICC/IF,FCM,ELISA |
| 基因名称 | NFE2L2 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived human NFE2L2 recombinant protein (Position:R34-N605). |
| 实际分子量 | 100KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | NFE2L2(nuclear factor (erythroid-derived 2)-like 2) also known as NRF2 or NFE2-RELATED TRANSCRIPTION FACTOR 2,is a transcription factor that in humans is encoded by the NFE2L2 gene.NFE2,NFE2L1,and NFE2L2 comprise a family of human genes encoding basic leucine zipper (bZIP) transcription factors.NFE2L2 induces the expression of various genes including those that encode for several antioxidant enzymes,and it may play a physiological role in the regulation of oxidative stress.The NFE2L2 gene is located on 2q31.2.The identification of somatic mutations that disrupt the NRF2-KEAP1 interaction to stabilize NRF2 and increase the constitutive transcription of NRF2 target genes indicated that enhanced reactive oxygen species (ROS) detoxification and additional NRF2 functions may in fact be tumorigenic.Oncogene-directed increased expression of Nrf2 is a mechanism for the activation of the Nrf2 antioxidant program evident in primary cells and tissues of mice expressing KRas(G12D) and BRaf(V619E),and in human pancreatic cancer. |
| Uniprot ID | Q16236 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot. |
| 基因名全称 | nuclear factor,erythroid 2 like 2 |
| 蛋白名全称 | Nuclear factor erythroid 2-related factor 2 |
| 推荐稀释比 | Western blot (WB) 1:500～2000 Immunohistochemistry (IHC) 1:50～400 Immunocytochemistry/Immunofluorescence (ICC/IF) 1:50～400 Flow cytometry (FCM) 1～3μg/1×106 cells Enzyme linked immunosorbent assay (ELISA) 1:100～1000 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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